Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history.

@article{Bonini2018CannabisSA,
  title={Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history.},
  author={Sara Anna Bonini and Marika Premoli and Simone Tambaro and Amit Kumar and Giuseppina Maccarinelli and Maurizio Memo and Andrea Mastinu},
  journal={Journal of ethnopharmacology},
  year={2018},
  volume={227},
  pages={
          300-315
        }
}
View on PubMed
doi.org
299 Citations
Highly Influential Citations
12
Background Citations
113
Methods Citations
6

299 Citations

Ethnobotany, Taxonomy and Phytochemistry of Cannabis sativa.

C. sativa is an ethnobotanical rich and phytochemical significant therapeutic plant that has its origin from Asia and because of lack of scientific research, the taxonomic aspects are still hidden.

The Medicinal Natural Products of Cannabis sativa Linn.: A Review

The biological potential of the plant parts, as well as the techniques for the extraction, isolation, and characterization of C. sativa compounds, are highlighted to highlight the clinical relevance and applications of cannabinoids and non-cannabinoid phenols in the prevention and treatment of life-threatening diseases.

Pharmacological properties, therapeutic potential, and legal status of Cannabis sativa L.: An overview

This mini‐review focuses on the medicinal importance of the plant and its legal status worldwide; the pharmacological compounds and its therapeutic potential along with the underlying public health concerns and future perspective are discussed.

Biosynthesis of Phytocannabinoids and Structural Insights: A Review

This study provides an overview of the different sources of phytocannabinoids and the biosynthesis of bioactive compounds involving various pathways is elucidated to help deepen the current understanding of the role of biotechnological approaches and the importance ofphytoc cannabinoidoids in different industrial applications.

Cannabidiol—from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer

The review is designed to provide an update regarding the multi-target effects of CBD in different types of cancer, and the main focus is on the latest in vitro and in vivo studies that present data regarding the anti-proliferative, pro-apoptotic, cytotoxic, anti-invasive,Anti-antiangiogenic,anti-inflammatory, and immunomodulatory properties of CBD together with their mechanisms of action.

Cannabis sativa L. Bioactive Compounds and Their Protective Role in Oxidative Stress and Inflammation

The chemical properties and bioavailability of THC and CBD, their main mechanisms of action, and their role in oxidative stress and inflammation are discussed.

Systematics and Botanical Characteristics of Industrial Hemp Cannabis Sativa L

The systematic affiliation of Cannabis has been controversial for many years, but today it is known that they belong to the order Rosales, family Cannabaceae, genus Cannabis, species – C. sativa L., with both industrial hemp and narcotic C. indica.

The Origin and Biomedical Relevance of Cannabigerol

Due to the relatively rapid metabolism of cannabigerol, determination of the concentration of the phytocannabinoid in blood or oral fluid can be used to determine cannabis use, and it seems obvious that new therapeutic approaches using CBG can be expected.

Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses

This review focuses on the potential therapeutic effects of Cannabis sativa and cannabinoids, as well as the acute and chronic toxic effects of cannabis use on various body systems.

Investigation of Cannabis sativa Phytochemicals as Anti-Alzheimer’s Agents: An In Silico Study

The effect of phytochemicals in Cannabis sativa on multiple culprit enzymes in Alzheimer’s disease, such as AChE, BChE (Butyrylcholinesterase), γ-secretase, and BACE-1 are analyzed to shed new light and opens new avenues for elucidating the role of bioactive compounds present in cannabis sativa in treating Alzheimer”s disease.
...

199 References

Cannabis sativa: The Plant of the Thousand and One Molecules

Prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.

Chemistry and Analysis of Phytocannabinoids and Other Cannabis Constituents

The Cannabis plant and its products consist of an enormous variety of chemicals. Some of the 483 compounds identified are unique to Cannabis, for example, the more than 60 cannabinoids, whereas the…

Phytocannabinoids as novel therapeutic agents in CNS disorders.

Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.

Observations suggest that the prenyl moiety of cannabinoids serves mainly as a modulator of lipid affinity for the olivetol core, a per se poorly active antibacterial pharmacophore, while their high potency definitely suggests a specific, but yet elusive, mechanism of activity.

Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids

  • L. Hanuš
  • Biology
    Medicinal research reviews
  • 2009
The present review deals with the history of the Cannabis sativa L. plant, its uses, constituent compounds and their biogeneses, and similarity to compounds from Radula spp.

The Cannabis Plant: Botanical Aspects

Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain

The current available data on the pharmacology of cannabis root components provide significant support to the historical and ethnobotanical claims of clinical efficacy, suggesting the need for reexamination of whole root preparations on inflammatory and malignant conditions employing modern scientific techniques.

Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain.

The roots of the cannabis plant have a long history of medical use stretching back millennia, but the therapeutic potential has been largely ignored in modern times, with only a few studies examining the composition of cannabis root and its medical potential.

A cannabigerol-rich Cannabis sativa extract, devoid of [INCREMENT]9-tetrahydrocannabinol, elicits hyperphagia in rats

CBG-BDS is a novel appetite stimulant, which may have greater potency than purified CBG, despite the absence of [INCREMENT]9-tetrahydrocannabinol in the extract.
...