Cannabis in cancer care

  title={Cannabis in cancer care},
  author={DI Abrams and Manuel Guzm{\'a}n},
  journal={Clinical Pharmacology \& Therapeutics},
  • DI AbramsM. Guzmán
  • Published 1 June 2015
  • Medicine, Biology
  • Clinical Pharmacology & Therapeutics
Cannabis has been used in medicine for thousands of years prior to achieving its current illicit substance status. Cannabinoids, the active components of Cannabis sativa, mimic the effects of the endogenous cannabinoids (endocannabinoids), activating specific cannabinoid receptors, particularly CB1 found predominantly in the central nervous system and CB2 found predominantly in cells involved with immune function. Delta‐9‐tetrahydrocannabinol, the main bioactive cannabinoid in the plant, has… 

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  • D. Abrams
  • Medicine, Biology
    Current oncology
  • 2016
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  • Medicine, Biology
    Current Treatment Options in Oncology
  • 2019
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Current evidence for use of medical cannabis and cannabinoids in cancer patients is weak, however, healthcare professionals are in an ideal role to monitor and educate patients using medical Cannabis and cannabinoids.



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The use of cannabinoids should be continued in the areas indicated, and further studies are needed to evaluate other potential uses in clinical oncology.

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Cannabinoids present an interesting therapeutic potential as antiemetics, appetite stimulants in debilitating diseases, analgesics, and in the treatment of multiple sclerosis, spinal cord injuries, Tourette's syndrome, epilepsy and glaucoma.

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  • R. Pertwee
  • Biology, Medicine
    British journal of pharmacology
  • 2009
Five strategies that have the potential to meet either the efficacy and/or the benefit‐to‐risk ratio of a cannabinoid receptor agonist are focused on.

Medicinal cannabis does not influence the clinical pharmacokinetics of irinotecan and docetaxel.

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