Cannabis as a Gateway Drug for Opioid Use Disorder
@article{Williams2020CannabisAA, title={Cannabis as a Gateway Drug for Opioid Use Disorder}, author={Arthur Robin Williams}, journal={The Journal of Law, Medicine \& Ethics}, year={2020}, volume={48}, pages={268 - 274} }
Cannabis use in some individuals can meaningfully introduce de novo risk for the initiation of opioid use and development of opioid use disorder. These risks may be particularly high during adolescence when cannabis use may disrupt critical periods of neurodevelopment. Current research studying the combination of genetic and environmental factors involved in substance use disorders is poorly understood. More research is needed, particularly to identify which adolescents are most at risk and to…
7 Citations
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States that legalize marijuana should help adolescents through regulation of advertising and availability of marijuana-infused edibles, which may assist in protecting neurodevelopment of the adolescent and young adult brain.
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The opioid crisis in the United States began in the 1990s, but the problem of drug addiction goes back much further: the ground was made fertile for expansion of opioid addiction into an epidemic, fueled by the drug industry.
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It is concluded that SLC6A3 represents an increasingly recognized risk with a growing number of familial mutants associated with neuropsychiatric and neurological disorders, and inclusion of its promoter region’s functional markers may help delineate condensate-based risk action.
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While the logistic regression model had lower performance than the neural network model, it matched the sensitivity of prior work, achieved a high level of significance, and yielded valuable inferences that implied that younger, less educated individuals who exhibit sensation-seeking behavior and are open to experience tend to be at higher risk for THC use.
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The incidence of patient reported marijuana use is increasing in the study population, but use was not associated with complications or percent weight loss, and more studies on the effects of marijuana use are warranted.
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