Cannabis – the Israeli perspective

@article{Mechoulam2016CannabisT,
  title={Cannabis – the Israeli perspective},
  author={Raphael Mechoulam},
  journal={Journal of Basic and Clinical Physiology and Pharmacology},
  year={2016},
  volume={27},
  pages={181 - 187}
}
  • R. Mechoulam
  • Published 1 May 2016
  • Medicine
  • Journal of Basic and Clinical Physiology and Pharmacology
Abstract Short overviews are presented on the historical uses of cannabis in the Middle East and on the more recent scientific and medical research on phytocannabinoids and the endocannabinoid system, with emphasis on research contributions from Israel. These are followed by examples of research projects and clinical trials with cannabinoids and by a short report on the regulation of medical marijuana in Israel, which at present is administered to over 22,000 patients. 

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References

SHOWING 1-10 OF 38 REFERENCES
A historical overview of chemical research on cannabinoids.
Early phytocannabinoid chemistry to endocannabinoids and beyond
TLDR
There have since been considerable advances in understanding of the endocannabinoid system and its function in the brain, which reveal potential therapeutic targets for a wide range of brain disorders.
Cannabis for Inflammatory Bowel Disease
TLDR
Evidence is gathering that manipulating the endocannabinoid system can have beneficial effects in IBD, but further research is required to declare cannabinoids a medicine.
The Use of a Synthetic Cannabinoid in the Management of Treatment‐Resistant Nightmares in Posttraumatic Stress Disorder (PTSD)
  • G. Fraser
  • Psychology, Medicine
    CNS neuroscience & therapeutics
  • 2009
TLDR
The results of this study indicate the potential benefits of nabilone, a synthetic cannabinoid, in patients with PTSD experiencing poor control of nightmares with standard pharmacotherapy.
The isolation and structure of delta-1-tetrahydrocannabinol and other neutral cannabinoids from hashish.
The isolation and elucidation of the structures of AMetrahydrocannabinol (A^THC), cannabigerol, cannabichromene, and cannabicyclol are described. A facile conversion of cannabidiol into A'-THC takes
Cannabis (Medical Marijuana) Treatment for Motor and Non–Motor Symptoms of Parkinson Disease: An Open-Label Observational Study
TLDR
The study suggests that cannabis might have a place in the therapeutic armamentarium of PD, with significant improvement of sleep and pain scores and no significant adverse effects of the drug were observed.
Molecular characterization of a peripheral receptor for cannabinoids
TLDR
The cloning of a receptor for cannabinoids is reported that is not expressed in the brain but rather in macrophages in the marginal zone of spleen, which helps clarify the non-psychoactive effects of cannabinoids.
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.
TLDR
Data show that CBD, through its combined immunosuppressive and anti-inflammatory actions, has a potent anti-arthritic effect in CIA.
Preliminary, Open-Label, Pilot Study of Add-On Oral Δ9-Tetrahydrocannabinol in Chronic Post-Traumatic Stress Disorder
TLDR
Orally absorbable Δ9-THC was safe and well tolerated by patients with chronic PTSD and caused a statistically significant improvement in global symptom severity, sleep quality, frequency of nightmares, and PTSD hyperarousal symptoms.
Cannabinoids Decrease the Th17 Inflammatory Autoimmune Phenotype
TLDR
The results show a unique cannabinoid modulation of the autoimmune cytokine milieu combining suppression of the pathogenic IL-17 and IL-6 cytokines along with boosting the expression of the anti-inflammatory cytokine IL-10.
...
...