Cannabis, cannabidiol, and epilepsy — From receptors to clinical response

@article{Szaflarski2014CannabisCA,
  title={Cannabis, cannabidiol, and epilepsy — From receptors to clinical response},
  author={Jerzy P. Szaflarski and E Martina Bebin},
  journal={Epilepsy \& Behavior},
  year={2014},
  volume={41},
  pages={277-282}
}
Plant-Derived and Endogenous Cannabinoids in Epilepsy
TLDR
There is some anecdotal evidence for the potential efficacy of cannabis in treating epilepsy, based on the observation that in individuals who smoke marijuana to treat epilepsy, cessation of cannabis use precipitates the re-emergence of convulsive seizures, whereas resuming consumption of this psychotropic drug controls epilepsy in a reproducible manner.
Therapeutic Potential of Cannabis, Cannabidiol, and Cannabinoid-Based Pharmaceuticals
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Data support a role for cannabis/cannabinoids in pain, seizure disorders, appetite stimulation, muscle spasticity, and treatment of nausea/vomiting, but much more careful research is required.
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Understanding of CBD’s efficacy and safety in the treatment of TRE has expanded significantly in the last few years, and data from both open-label expanded access programs (EAPs) and randomized placebo-controlled trials (RCTs) of a highly purified oral preparation of CBD are presented.
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TLDR
There is indeed sufficient supporting data for clinical development and important antiepileptic effects and the currently ongoing clinical studies will permit the real usefulness of CBD and possibly other cannabinoids.
Cannabidiol (CBD) and cognition in epilepsy
Cannabinoids and Epilepsy
TLDR
These studies suggest that CBD avoids the psychoactive effects of the endocannabinoid system to provide a well-tolerated, promising therapeutic for the treatment of seizures, while whole-plant cannabis can both contribute to and reduce seizures.
The current state and potential direction of cannabis research
TLDR
The underlying conditions that are significantly controlled or modulated by cannabis are discussed to provide the medical community with a broad synopsis of recent research trials on Cannabis sativa that have indicated its medicinal benefits.
Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agents
TLDR
Judging from clinical findings reported so far, CBD and CBD‐enriched preparations have great potential utility, but uncertainties regarding sourcing, long‐term safety, abuse potential, and regulatory dilemmas remain.
Cannabidiol and epilepsy: Rationale and therapeutic potential.
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References

SHOWING 1-10 OF 61 REFERENCES
Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders
TLDR
CBD bears investigation in epilepsy and other neuropsychiatric disorders, including anxiety, schizophrenia, addiction, and neonatal hypoxic‐ischemic encephalopathy, however, data from well‐powered double‐blind randomized, controlled studies on the efficacy of pure CBD for any disorder is lacking.
Cannabis-related Stroke: Myth or Reality?
TLDR
The more common effects described as beneficial are glaucoma, analgesia, appetite in AIDS patients, tremor, Parkinson disease, spasticity in multiple sclerosis, epilepsia, anxiolytic, or antidepressive actions, and psychological and physical dependence are described as chronic effects of cannabis use.
Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects.
Cannabidiol and medical marijuana for the treatment of epilepsy
TLDR
This edition of Epilepsia presents a series of articles on the potential use of CBD and medical marijuana for epilepsy, including an Invited Review on this topic and two papers in the authors' Controversy in Epilepsy series.
Therapeutic potential of cannabinoid medicines.
  • P. Robson
  • Biology, Medicine
    Drug testing and analysis
  • 2014
TLDR
Clinical research exploring the potential of cannabinoid medicines in the following indications are reviewed: symptomatic relief in multiple sclerosis, chronic neuropathic pain, intractable nausea and vomiting, loss of appetite and weight in the context of cancer or AIDS, psychosis, epilepsy, addiction, and metabolic disorders.
The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
TLDR
A role for the endogenous cannabinoid system in modulating neuroexcitation is defined and plasticity of the CB1 receptor occurs with epilepsy, and data indicate not only anticonvulsant activity of exogenously applied cannabinoids but also suggest that endogenous cannabinoid tone modulates seizure termination and duration.
Pharmacology and effects of cannabis: A brief review
  • C. Ashton
  • Medicine
    British Journal of Psychiatry
  • 2001
TLDR
Cannabinoids derived from herbal cannabis interact with endogenous cannabinoid systems in the body and cause dose-related impairments of psychomotor performance with implications for car and train driving, aeroplane piloting and academic performance.
Cannabidiol Attenuates the Appetitive Effects of Δ9-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis
TLDR
The findings suggest that CBD has potential as a treatment for cannabis dependence and the acute modulation of the incentive salience of drug cues by CBD may possibly generalize to a treatment to other addictive disorders.
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