Cannabinoids reveal the necessity of hippocampal neural encoding for short-term memory in rats.

@article{Hampson2000CannabinoidsRT,
  title={Cannabinoids reveal the necessity of hippocampal neural encoding for short-term memory in rats.},
  author={R. E. Hampson and Sam A. Deadwyler},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 23},
  pages={8932-42}
}
The memory-disruptive effects of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and the synthetic cannabinoid WIN 55,212-2 (WIN-2) were assessed in rats exposed to varying doses of each drug (Delta(9)-THC, 0.5-2.0 mg/kg; WIN-2, 0.25-0.75 mg/kg) during performance of a delayed nonmatch to sample (DNMS) task. Cannabinoids affected performance in a dose x delay-dependent manner, with WIN-2 showing a potency more than four times that of Delta(9)-THC. These effects on DNMS performance were eliminated… CONTINUE READING
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1998b) Methods, results and issues related to recording neural ensembles

  • RE Hampson, SA Deadwyler
  • 1998
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