Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores

@article{Zhuang2005CannabinoidsPN,
  title={Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores},
  author={S. Zhuang and D. Bridges and E. Grigorenko and Stephen McCloud and S. Deadwyler},
  journal={Neuropharmacology},
  year={2005},
  volume={48},
  pages={1086-1096}
}
Exogenously administered cannabinoids are neuroprotective in several different cellular and animal models. In the current study, two cannabinoid CB1 receptor ligands (WIN 55,212-2, CP 55,940) markedly reduced hippocampal cell death, in a time-dependent manner, in cultured neurons subjected to high levels of NMDA (15 microM). WIN 55,212-2 was also shown to inhibit the NMDA-induced increase in intracellular calcium concentration ([Ca2+](i)) indicated by FURA-2 fluorescence imaging in the same… Expand
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References

SHOWING 1-10 OF 86 REFERENCES
Cannabinoids Enhance NMDA-Elicited Ca2+ Signals in Cerebellar Granule Neurons in Culture
  • 106
  • PDF
Cannabinoids and Neuroprotection in Global and Focal Cerebral Ischemia and in Neuronal Cultures
  • 452
  • PDF
Cannabinoid and kappa opioid receptors reduce potassium K current via activation of G(s) proteins in cultured hippocampal neurons.
  • 81
  • PDF
Cannabinoids modulate potassium current in cultured hippocampal neurons.
  • 168
Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons.
  • 540
  • Highly Influential
  • PDF
Cannabinoid receptors differentially modulate potassium A and D currents in hippocampal neurons in culture.
  • 93
  • PDF
Mechanisms of Cannabinoid Inhibition of GABAASynaptic Transmission in the Hippocampus
  • 393
  • PDF
Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process.
  • 245
Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants.
  • 656
  • Highly Influential
  • PDF
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