Cannabinoids prevent depressive-like symptoms and alterations in BDNF expression in a rat model of PTSD

@article{Burstein2018CannabinoidsPD,
  title={Cannabinoids prevent depressive-like symptoms and alterations in BDNF expression in a rat model of PTSD},
  author={O Mualem Burstein and Noa Shoshan and Ravid Doron and Irit Akirav},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2018},
  volume={84},
  pages={129-139}
}
Posttraumatic stress disorder (PTSD) is a debilitating condition highly comorbid with depression. The endocannabinoid (eCB) system and brain-derived neurotrophic factor (BDNF) are suggestively involved in both disorders. We examined whether cannabinoids can prevent the long-term depressive-like symptoms induced by exposure to the shock and situational reminders (SRs) model of PTSD. The CB1/2 receptor agonist WIN55,212-2 (0.5 mg/kg; i.p.), the fatty acid hydrolase (FAAH) inhibitor URB597 (0.3 mg… CONTINUE READING