Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors

@article{Agarwal2007CannabinoidsMA,
  title={Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors},
  author={Nitin Kumar Agarwal and P{\'a}l Pacher and Irmgard Tegeder and Fumimasa Amaya and Cristina E. Constantin and Gary J Brenner and Tiziana Rubino and Christoph W Michalski and Giovanni Marsicano and Krisztina Monory and Ken Mackie and Claudiu Marian and Sandor Batkai and Daniela Parolaro and Michael J. M. Fischer and Peter W. Reeh and George Kunos and Michaela Kress and Beat Lutz and Clifford J. Woolf and Rohini Kuner},
  journal={Nature Neuroscience},
  year={2007},
  volume={10},
  pages={870-879}
}
Although endocannabinoids constitute one of the first lines of defense against pain, the anatomical locus and the precise receptor mechanisms underlying cannabinergic modulation of pain are uncertain. Clinical exploitation of the system is severely hindered by the cognitive deficits, memory impairment, motor disturbances and psychotropic effects resulting from the central actions of cannabinoids. We deleted the type 1 cannabinoid receptor (CB1) specifically in nociceptive neurons localized in… 
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Targeting the cannabinoid system for pain relief?
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    Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists
  • 2013
Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain
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Recent studies of the effects of inhibition of metabolism of endocannabinoids versus uptake of endOCannabinoids on nociceptive processing in models of inflammatory and neuropathic pain are reviewed.
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