Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum.

@article{Pandolfo2011CannabinoidsIT,
  title={Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum.},
  author={Pablo Pandolfo and Vasco Silveirinha and Alexandre dos Santos-Rodrigues and Laurent Venance and Catherine A. Ledent and Reinaldo Naoto Takahashi and Rodrigo A Cunha and Attila K{\"o}falvi},
  journal={European journal of pharmacology},
  year={2011},
  volume={655 1-3},
  pages={38-45}
}
Adenosine, dopamine and endocannabinoids strictly modulate the release of one another in the dorsolateral striatum thereby controlling synaptic plasticity. As a second level of interaction, they regulate the action of one another via receptor heteromer formation. Here we investigated a putative third level of interaction, i.e. the possible control by cannabinoids of synaptic dopamine and adenosine reuptake. We found that a large number of endo- and exogenous cannabinoid ligands inhibit the… CONTINUE READING

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