Cannabinoids inhibit pre- and postjunctionally sympathetic neurotransmission in rat mesenteric arteries.

  title={Cannabinoids inhibit pre- and postjunctionally sympathetic neurotransmission in rat mesenteric arteries.},
  author={Vera Ralevic and David A. Kendall},
  journal={European journal of pharmacology},
  volume={444 3},
  • V. RalevicD. Kendall
  • Published 31 May 2002
  • Biology, Chemistry, Medicine
  • European journal of pharmacology

Cannabinoid CB1 receptor-mediated inhibition of noradrenaline release in guinea-pig vessels, but not in rat and mouse aorta

The results show that the postganglionic sympathetic nerve fibres in the guinea-pig aorta, but not in the rat or mouse aortA, are endowed with presynaptic inhibitory cannabinoid CB1 receptors; such receptors also occur in guineapig pulmonary artery, basilar artery and portal vein.

Search for an endogenous cannabinoid-mediated effect in the sympathetic nervous system

The lack of effect of the CB1 receptor antagonist rimonabant indicates that, even under conditions favouring endocannabinoid synthesis, endoc cannabinoidoid-mediated presynaptic inhibition is not operating in the sympathetic nervous system of the pithed rat.

Effects of cannabinoids on neurotransmission.

It is characteristic for the ubiquitous operation of CB1 receptor-mediated presynaptic inhibition that antagonistic components of functional systems (for example, the excitatory and inhibitory inputs of the same neuron) are simultaneously inhibited by cannabinoids.

Reduced Noradrenergic Signaling in the Spleen Capsule in the Absence of CB1 and CB2 Cannabinoid Receptors

A role for CB1 and/or CB2 in noradrenergic splenic contraction is found in Cnr1-/-/Cnr2-/- mouse spleens, likely due to decreased expression of capsular α1AR.

ATP as a sympathetic neurotransmitter

The present study supports the observation that ATP becomes a more important sympathetic neurotransmitter under conditions of raised tone in contrast to when tone is absent.

Clinical Pharmacodynamics of Cannabinoids

The knowledge of the pharmacodynamics of cannabinoids has considerably increased within the past decade due to the detection of an endogenous cannabinoid system with specific receptors and their endogenous ligands, including THC, which is an agonist to both the CB1 and the CB2 subtype of these receptors.

Pharmacokinetics and Pharmacodynamics of Cannabinoids

Properties of cannabis that might be of therapeutic use include analgesia, muscle relaxation, immunosuppression, sedation, improvement of mood, stimulation of appetite, antiemesis, lowering of intraocular pressure, bronchodilation, neuroprotection and induction of apoptosis in cancer cells.

Cannabinoid pharmacology in the cardiovascular system: potential protective mechanisms through lipid signalling

  • C. HileyW. Ford
  • Biology, Chemistry
    Biological reviews of the Cambridge Philosophical Society
  • 2004
Current evidence suggests that endocannabinoids have important protective roles in pathophysiological conditions such as shock and myocardial infarction and their cardiovascular effects and the receptors mediating them are the subject of increasing investigative interest.



Cannabinoid CB1 receptor-mediated inhibition of the neurogenic vasopressor response in the pithed rat

The neurogenic vasopressor response in the pithed rat can be modulated via cannabinoid CB1 receptors probably located presynaptically on the postganglionic sympathetic nerve fibres innervating resistance vessels.

Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB 1 receptors on peripheral sympathetic nerves

Results suggest that activation of presynaptic CB1 receptors located on peripheral sympathetic nerve terminals mediate sympathoinhibitory effects in vitro and in vivo.

Effects of cannabinoids on sympathetic and parasympathetic neuroeffector transmission in the rabbit heart.

The results indicate that cannabinoids, by activating CB(1) cannabinoid receptors, inhibit sympathetic and vagal neuroeffector transmission in the heart and may have an inhibitory action on both pre- and postganglionic vagal neurons.

Mesenteric vasodilation mediated by endothelial anandamide receptors.

It is concluded that anandamide-induced mesenteric vasodilation is mediated by an endothelially located SR141716A-sensitive "anandamide receptor" distinct from CB1 cannabinoid receptors and that activation of such receptors by an endocannabinoid, possibly anandamia, contributes to LPS-induced Mesenteric Vasodilation in vivo.

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

It is shown that the vasodilator response to anandamide in isolated arteries is capsaicin-sensitive and accompanied by release of calcitonin-gene-related peptide (CGRP), which indicates that the vanilloid receptor may be another molecular target for endogenousAnandamide, besides cannabinoid receptors, in the nervous and cardiovascular systems.

Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.

  • Z. JáraiJ. Wagner G. Kunos
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1999
It is suggested that Abn-cbd and cannabidiol are a selective agonist and antagonist, respectively, of an as-yet-unidentified endothelial receptor for anandamide, activation of which elicits NO-independent mesenteric vasodilation, possibly by means of the release of an endothelium-derived hyperpolarizing factor (EDHF).

Characterization of cannabinoid receptors coupled to vasorelaxation by endothelium-derived hyperpolarizing factor

The present observations point to the involvement of a cannabinoid receptor, which may be CB1 or CB1-like, in EDHF-mediated vasorelaxation, which is currently proposed to be an endothelium-derived hyperpolarizing factor.

The actions of some cannabinoid receptor ligands in the rat isolated mesenteric artery

The results show that these compounds exert both receptor‐dependent and ‐independent effects on agonist‐induced calcium mobilization in the rat isolated mesenteric artery.