Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells.

@article{Lu2008CannabinoidsIH,
  title={Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells.},
  author={Tzong-Shi Lu and Hava Karsenty Avraham and Seyha Seng and Souvenir D. Tachado and Henry Koziel and Alexandros Makriyannis and Shalom Avraham},
  journal={Journal of immunology},
  year={2008},
  volume={181 9},
  pages={
          6406-16
        }
}
HIV-1 infection has significant effect on the immune system as well as on the nervous system. Breakdown of the blood-brain barrier (BBB) is frequently observed in patients with HIV-associated dementia (HAD) despite lack of productive infection of human brain microvascular endothelial cells (HBMEC). Cellular products and viral proteins secreted by HIV-1 infected cells, such as the HIV-1 Gp120 envelope glycoprotein, play important roles in BBB impairment and HIV-associated dementia development… CONTINUE READING

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