Cannabinoids in the Treatment of Insomnia Disorder: A Systematic Review and Meta-Analysis

  title={Cannabinoids in the Treatment of Insomnia Disorder: A Systematic Review and Meta-Analysis},
  author={C.S.K. Bhagavan and Stacey Kung and Marjan Doppen and M. John and Iva Vakalalabure and Karen Oldfield and Irene Braithwaite and Giles Newton-Howes},
  journal={CNS Drugs},
  pages={1217 - 1228}
Insomnia is associated with significant comorbidity, disability and impact on quality of life and, despite advances in pharmacotherapy and psychotherapy, remains a significant burden to society. Cannabinoids are gaining acceptance for use as medicines in the treatment of insomnia disorder. We conducted a systematic review and meta-analysis to evaluate the efficacy of cannabinoids in the treatment of insomnia disorder. We performed a systematic review of the PubMed, Cochrane Library, MEDLINE… 

Use of Cannabidiol in the Management of Insomnia: A Systematic Review.

CBD alone or with equal quantities of THC may be beneficial in alleviating the symptoms of insomnia and future research assessing CBDs effectiveness in population of patients specifically with insomnia utilizing validated subjective and objective measures is necessary before definitive inferences can be made.

Cannabis use in patients with insomnia and sleep disorders: Retrospective chart review

The importance of a pharmacist’s role in the management of cannabis-based therapy, including ongoing supportive care, follow-up and medication management, is highlighted.

The Effects of Cannabinoids on Sleep

It is shown that cannabis products have minimal to no effects on sleep disorders and may have deleterious effects in some individuals and further research examining the differential impact of the various types of cannabinoids that are currently available on each of these sleep disorders is required.

The safety and relative effectiveness of non-psychoactive cannabinoid formulations for the improvement of sleep: a double-blinded, randomized controlled trial

Chronic use of a low dose of CBD is safe and could improve sleep quality, though these effects do not exceed that of 5 mg melatonin, and the addition of low doses of CBN and CBC may not improve the effect of formulations containing CBD or melatonin isolate.

Recent cannabis use and nightly sleep duration in adults: a population analysis of the NHANES from 2005 to 2018

Recent cannabis use was associated with the extremes of nightly sleep duration in a nationally representative sample of adults, with suggestions of a dose–response relationship.

Cannabis zur Behandlung des klimakterischen Syndroms!?

  • P. Stute
  • Gynäkologische Endokrinologie
  • 2021
Hintergrund. Der indische Hanf, Cannabis sativa variation indica, enthält (–)-Δ9-Tetrahydrocannabinol (Δ9-THC) und über 100 chemisch verwandte Substanzen, darunter das (–)-Cannabidiol (CBD). Die

Sociodemographic Characteristics Associated With and Prevalence and Frequency of Cannabis Use Among Adults in the US

Young, male, Black, and Native American individuals and individuals with low educational attainment and income were more likely to engage in higher frequency cannabis use, and higher-frequency use among these populations may warrant more attention from policymakers and public health officials.

Single-channel EEG based insomnia detection with domain adaptation




The use of cannabinoids for sleep: A critical review on clinical trials.

A critical review of clinical studies examining the effects of cannabinoids on subjective and objective measures of sleep found many of the studies suggested that cannabinoids could improve sleep quality, decrease sleep disturbances, and decrease sleep onset latency.

The assessment and management of insomnia: an update

There are an array of interventions which have been demonstrated to have therapeutic effects in insomnia in trials with the above features, and whose risk/benefit profiles have been well characterized, and these interventions can form the basis for systematic, evidence‐based treatment of insomnia in clinical practice.

The Effects of Nabilone on Sleep in Fibromyalgia: Results of a Randomized Controlled Trial

Nabilone is effective in improving sleep in patients with FM and is well tolerated, and low-dose nabilone given once daily at bedtime may be considered as an alternative to amitriptyline.

Cannabidiol in Anxiety and Sleep: A Large Case Series.

A large retrospective case series involving clinical application of CBD for anxiety and sleep complaints as an adjunct to usual treatment found CBD was well tolerated in all but 3 patients.

Cannabis, Cannabinoids, and Sleep: a Review of the Literature

The state of research on cannabis and sleep up to 2014 is summarized and synthetic cannabinoids such as nabilone and dronabinol may have short-term benefit for sleep apnea due to their modulatory effects on serotonin-mediated apneas.

European guideline for the diagnosis and treatment of insomnia

This European guideline for the diagnosis and treatment of insomnia was developed by a task force of the European Sleep Research Society, with the aim of providing clinical recommendations for the

The Prevalence of Insomnia Subtypes in Relation to Demographic Characteristics, Anxiety, Depression, Alcohol Consumption and Use of Hypnotics

The findings suggest that there are major differences between the insomnia subtypes, both regarding demographics, but also in terms of how the complaints may affect daily life.