Cannabinoids in male mice: effects on fertility and spermatogenesis.

@article{Dalterio1982CannabinoidsIM,
  title={Cannabinoids in male mice: effects on fertility and spermatogenesis.},
  author={Susan L. Dalterio and Fouad Mohamed Badr and Andrzej Bartke and D L Mayfield},
  journal={Science},
  year={1982},
  volume={216 4543},
  pages={
          315-6
        }
}

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The program involving marijuana is seeking to establish not only whether there is a teratogenic hazard common to various species but also whether subteratogenic deviations, i.e., morphological, physiological, or behavioral effects, might be a consequence of the substances contained in this plant.

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This chapter discusses neuroendocrine and Behavioral Development During Puberty and Hormonal Influences on Cancer Progression and Prognosis, and the role of Androgen Receptor in this development.

Teratologic evaluation of delta9-tetrahydrocannabinol in mice, including a review of the literature.

Treatment with delta9-THC in sesame oil had no effect on the maternal weight gain, prenatal mortality rate, fetal weight, and the frequency of gross external, internal, and skeletal abnormalities in pregnant CD1 mice.

Cannabinoids inhibit testosterone secretion by mouse testes in vitro.

Addition of delta-9-tetrahydrocannabinol or cannabinol to an incubation medium containing decapsulated mouse testes caused a significant reduction in the accumulation of testosterone in the medium.

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In this limited study of mitotic cells the incidence of metaphase aberrations in cannabinoid-treated animals was 5-7 times greater than in controls; the number of micronuclei was affected by THC dosage, but not by frequency of exposure.

Delta9-tetrahydrocannabinol increase plasma testosterone concentrations in mice.

Oral administration of delta 9-tetrahydrocannabinol had a biphasic effect on plasma testosterone concentrations in male mice, causing rapid sustained increases at low doses and subsequent decreases at higher doses, suggesting this cannabinoid may interact with gonadotropin and directly influence testicular steroidogenesis in vivo.

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The air-drying method gives improved spreading of the chromosomes and less cell breakage compared with squash techniques, suitable for stages of male meiosis in which the chromosomes are condensed.