Cannabinoids in male mice: effects on fertility and spermatogenesis.

  title={Cannabinoids in male mice: effects on fertility and spermatogenesis.},
  author={Susan L. Dalterio and Fouad Mohamed Badr and Andrzej Bartke and D L Mayfield},
  volume={216 4543},

The effects of cannabidiol on male reproductive system: A literature review

It is possible to conclude that CBD has negative effects on the reproductive system of males from the studies identified, however, knowledge is still limited, and additional research is required to elucidate fully the mechanisms of action, as well as the reversibility of CBD effects onThe reproductive system.

The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis

The data indicate that male mouse germ cells possess an active and complete ECS, which is modulated during meiosis, and suggest the presence of an autocrine endocannabinoid signal during spermatogenesis, and play a pivotal role in promoting the meiotic progression of germ cells by activating CB2 receptors.

Marijuana effects on the endocrine and reproductive systems. Discussion and recommendations.

NIDA Research Monographs are prepared by the research divisions of the National Institute on Drug Abuse and published by its Office of Science to provide critical reviews of research problem areas and techniques.

Chronic delta-9-tetrahydrocannabinol exposure impacts testicular volume and male reproductive health in rhesus macaques

To determine the dose-dependent effect of contemporary delta-9-tetrahydrocannabinol (THC) exposure on male testes and reproductive health in a non-human primate model (NHP), a research animal study finds adverse impact on male reproductive health.

Statement on safety of cannabidiol as a novel food: data gaps and uncertainties

Considering the significant uncertainties and data gaps, the Panel concludes that the safety of CBD as a NF cannot currently be established.

Effects of marijuana on reproductive health: preconception and gestational effects

With the increasing prevalence of marijuana use, there is an urgent need for evidence-driven recommendations and guidelines for couples interested in conception, affected by infertility or who are expecting.

The relationship between cannabis use and IVF outcome—a cohort study

The results may provide some reassurance for the lack of any demonstrable detrimental effects of cannabis consumption on IVF outcomes, and a larger prospective study is needed to validate its findings.




The program involving marijuana is seeking to establish not only whether there is a teratogenic hazard common to various species but also whether subteratogenic deviations, i.e., morphological, physiological, or behavioral effects, might be a consequence of the substances contained in this plant.

Vitamins and hormones : advances in research and applications

This chapter discusses neuroendocrine and Behavioral Development During Puberty and Hormonal Influences on Cancer Progression and Prognosis, and the role of Androgen Receptor in this development.

Teratologic evaluation of delta9-tetrahydrocannabinol in mice, including a review of the literature.

Treatment with delta9-THC in sesame oil had no effect on the maternal weight gain, prenatal mortality rate, fetal weight, and the frequency of gross external, internal, and skeletal abnormalities in pregnant CD1 mice.

Cannabinoids inhibit testosterone secretion by mouse testes in vitro.

Addition of delta-9-tetrahydrocannabinol or cannabinol to an incubation medium containing decapsulated mouse testes caused a significant reduction in the accumulation of testosterone in the medium.

Influence of cannabinoids on somatic cells in vivo.

In this limited study of mitotic cells the incidence of metaphase aberrations in cannabinoid-treated animals was 5-7 times greater than in controls; the number of micronuclei was affected by THC dosage, but not by frequency of exposure.

Delta9-tetrahydrocannabinol increase plasma testosterone concentrations in mice.

Oral administration of delta 9-tetrahydrocannabinol had a biphasic effect on plasma testosterone concentrations in male mice, causing rapid sustained increases at low doses and subsequent decreases at higher doses, suggesting this cannabinoid may interact with gonadotropin and directly influence testicular steroidogenesis in vivo.


The air-drying method gives improved spreading of the chromosomes and less cell breakage compared with squash techniques, suitable for stages of male meiosis in which the chromosomes are condensed.