Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential
@article{Ashton2005CannabinoidsIB, title={Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential}, author={C. Heather Ashton and P. Brian Moore and Peter Gallagher and Allan H. Young}, journal={Journal of Psychopharmacology}, year={2005}, volume={19}, pages={293 - 300} }
Bipolar affective disorder is often poorly controlled by prescribed drugs. Cannabis use is common in patients with this disorder and anecdotal reports suggest that some patients take it to alleviate symptoms of both mania and depression. We undertook a literature review of cannabis use by patients with bipolar disorder and of the neuropharmacological properties of cannabinoids suggesting possible therapeutic effects in this condition. No systematic studies of cannabinoids in bipolar disorder…
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References
SHOWING 1-10 OF 143 REFERENCES
The use of cannabis as a mood stabilizer in bipolar disorder: anecdotal evidence and the need for clinical research.
- Psychology, MedicineJournal of psychoactive drugs
- 1998
The authors present case histories indicating that a number of patients find cannabis (marihuana) useful in the treatment of their bipolar disorder, and describe the use of cannabis as a supplement to lithium or for relief of lithium's side effects.
Drug abuse and bipolar disorder: comorbidity or misdiagnosis?
- Psychology, MedicineJournal of affective disorders
- 2001
The Pharmacological Treatment of Bipolar Affective Disorder: Practice Is Improving but Could Still be Better
- Psychology, MedicineJournal of psychopharmacology
- 2003
Practice in the population studied is nearer than treatment described in previous work to that suggested in the literature, but it still falls short in a number of respects of such recommendations as exist and this requires further examination and monitoring.
Does Quetiapine Have Mood Altering Properties?
- Psychology, MedicineJournal of psychopharmacology
- 2004
These cases indicate that a side-effect of quetiapine may be mood elevation, an ability to elevate mood while controlling psychoses would be helpful in the treatment of post-psychotic and bipolar depression.
Adverse effects of cannabis and cannabinoids.
- MedicineBritish journal of anaesthesia
- 1999
It is timely to review the adverse effects of cannabis, especially in view of the increased prevalence of its recreational use in the UK, increased potency of modern preparations and present interest in the therapeutic possibilities of cannabinoids.
Psychiatric effects of cannabis
- Medicine, PsychologyBritish Journal of Psychiatry
- 2001
To re-evaluate the adverse effects of cannabis in the general population and among vulnerable individuals, including those with serious psychiatric disorders, a wide-ranging review of the topics related to these issues is conducted.
Anticonvulsants as mood stabilisers
- Psychology, Medicine
- 1999
Research into the use of anticonvulsants as alternatives or supplements to lithium in the treatment of bipolar affective disorder, particularly when outcome is poor, is highlighted.
Hypnotic and Antiepileptic Effects of Cannabidiol
- Psychology, MedicineJournal of clinical pharmacology
- 1981
Abstract: Clinical trials with cannabidiol (CBD) in healthy volunteers, insomniacs, and epileptic patients conducted in the authors' laboratory from 1972 up to the present are reviewed. Acute doses…
The impact of substance abuse on the course of bipolar disorder
- Psychology, MedicineBiological Psychiatry
- 2000