Cannabinoids for gastrointestinal diseases: potential therapeutic applications

  title={Cannabinoids for gastrointestinal diseases: potential therapeutic applications},
  author={G. Carlo and A. Izzo},
  journal={Expert Opinion on Investigational Drugs},
  pages={39 - 49}
  • G. Carlo, A. Izzo
  • Published 2003
  • Medicine
  • Expert Opinion on Investigational Drugs
  • Δ9-Tetrahydrocannabinol (the active ingredient of marijuana), as well as endogenous and synthetic cannabinoids, exert many biological functions by activating two types of cannabinoid receptors, CB1 and CB2 receptors. CB1 receptors have been detected on enteric nerves, and pharmacological effects of their activation include gastroprotection, reduction of gastric and intestinal motility and reduction of intestinal secretion. The digestive tract also contains endogenous cannabinoids (i.e., the… CONTINUE READING
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