Cannabinoids for gastrointestinal diseases: potential therapeutic applications
@article{Carlo2003CannabinoidsFG, title={Cannabinoids for gastrointestinal diseases: potential therapeutic applications}, author={Giulia Di Carlo and Angelo A. Izzo}, journal={Expert Opinion on Investigational Drugs}, year={2003}, volume={12}, pages={39 - 49} }
Δ9-Tetrahydrocannabinol (the active ingredient of marijuana), as well as endogenous and synthetic cannabinoids, exert many biological functions by activating two types of cannabinoid receptors, CB1 and CB2 receptors. CB1 receptors have been detected on enteric nerves, and pharmacological effects of their activation include gastroprotection, reduction of gastric and intestinal motility and reduction of intestinal secretion. The digestive tract also contains endogenous cannabinoids (i.e., the…
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Modulation of the gut endogenous cannabinoid system may provide a useful therapeutic target for disorders of gastrointestinal motility.
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GASTROINTESTINAL ENDOCANNABINOID SYSTEM: MULTIFACETED ROLES IN THE HEALTHY AND INFLAMED INTESTINE
- Biology, MedicineClinical and experimental pharmacology & physiology
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1 The endogenous cannabinoid (endocannabinoid) system is emerging as a key modulator of intestinal physiology, influencing motility, secretion, epithelial integrity and immune function in the gut, in…
Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation
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This review of the current knowledge of CB2 receptors in the gastrointestinal tract highlights its role in regulating abnormal motility, modulating intestinal inflammation and limiting visceral sensitivity and pain.
The endocannabinoid system in the physiology and pathophysiology of the gastrointestinal tract
- Biology, MedicineJournal of Molecular Medicine
- 2005
An alternative and promising avenue for therapeutic applications resides in the treatment with CB1 receptor agonists that are unable to cross the blood–brain barrier, or with compounds that inhibit the degradation of endogenous ligands (endocannabinoids) of CB1 receptors, hence prolonging the activity of the endocannabinoid system.
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The present review shows that cannabinoids exert their anti-cancer effects in a number of ways and in a variety of tissues, and strongly support the idea that cannabinoids may induce benefical effect in cancer treatment.
Endocannabinoids and the gastrointestinal tract: what are the key questions?
- Medicine, BiologyBritish journal of pharmacology
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Cannabinoid (CB1) receptor activation acts neuronally, reducing GI motility, diarrhoea, pain, transient lower oesophageal sphincter relaxations (TLESRs) and emesis, and promoting eating. CB2 receptor…
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