Cannabinoids as novel anti-inflammatory drugs.

@article{Nagarkatti2009CannabinoidsAN,
  title={Cannabinoids as novel anti-inflammatory drugs.},
  author={Prakash S. Nagarkatti and Rupal Pandey and Sadiye Amcaoglu Rieder and Venkatesh L Hegde and Mitzi Nagarkatti},
  journal={Future medicinal chemistry},
  year={2009},
  volume={1 7},
  pages={
          1333-49
        }
}
Cannabinoids are a group of compounds that mediate their effects through cannabinoid receptors. The discovery of Δ9-tetrahydrocannabinol (THC) as the major psychoactive principle in marijuana, as well as the identification of cannabinoid receptors and their endogenous ligands, has led to a significant growth in research aimed at understanding the physiological functions of cannabinoids. Cannabinoid receptors include CB1, which is predominantly expressed in the brain, and CB2, which is primarily… 

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References

SHOWING 1-10 OF 149 REFERENCES
Cannabinoids and the immune system: Potential for the treatment of inflammatory diseases?
Activation through Cannabinoid Receptors 1 and 2 on Dendritic Cells Triggers NF-κB-Dependent Apoptosis: Novel Role for Endogenous and Exogenous Cannabinoids in Immunoregulation1
TLDR
It is demonstrated for the first time that endogenous and exogenous cannabinoids may suppress the immune response through their ability to induce apoptosis in DCs.
Cannabinoid receptor as a novel target for the treatment of prostate cancer.
TLDR
The results suggest that WIN-55,212-2 or other non-habit-forming cannabinoid receptor agonists could be developed as novel therapeutic agents for the treatment of prostate cancer.
Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
TLDR
Mechanistic insight is provided into beneficial effects provided by cannabinoid receptor CB2 modulation in neurodegenerative diseases, particularly AD.
Cannabinoid receptors as therapeutic targets.
  • K. Mackie
  • Biology, Medicine
    Annual review of pharmacology and toxicology
  • 2006
TLDR
This review considers the components of the endocannabinoid system and discusses some of the most promising endoc cannabinoidoid-based therapies.
Arachidonylethanolamide Induces Apoptosis of Human Glioma Cells through Vanilloid Receptor‐1
TLDR
It is observed that AEA induced apoptosis in long-term and recently established glioma cell lines via aberrantly expressed vanilloid receptor-1 (VR1), which shows that the selective targeting of VR1 by AEA or more stable analogues is an attractive research area for the treatment of gliomas.
The endocannabinoid system: physiology and pharmacology.
TLDR
New tools have enabled the study of the physiological roles played by the endocannabinoids and have opened up new strategies in the treatment of pain, obesity, neurological diseases including multiple sclerosis, emotional disturbances such as anxiety and other psychiatric disorders including drug addiction.
...
...