Cannabinoids and the skeleton: from marijuana to reversal of bone loss.

  title={Cannabinoids and the skeleton: from marijuana to reversal of bone loss.},
  author={Itai A. Bab and Andreas Zimmer and Eitan Melamed},
  journal={Annals of medicine},
  volume={41 8},
The active component of marijuana, Delta(9)-tetrahydrocannabinol, activates the CB1 and CB2 cannabinoid receptors, thus mimicking the action of endogenous cannabinoids. CB1 is predominantly neuronal and mediates the cannabinoid psychotropic effects. CB2 is predominantly expressed in peripheral tissues, mainly in pathological conditions. So far the main endocannabinoids, anandamide and 2-arachidonoylglycerol, have been found in bone at 'brain' levels. The CB1 receptor is present mainly in… CONTINUE READING
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