Cannabinoids and psychosis: current challenges of mechanistic toxicology

  title={Cannabinoids and psychosis: current challenges of mechanistic toxicology},
  author={Rui Malheiro and Telma M. Gomes and Helena Carmo and F{\'e}lix Carvalho and Jo{\~a}o Pedro Silva},
  journal={Toxicological Risk Assessment and Multi-System Health Impacts from Exposure},


Psychosis and synthetic cannabinoids
Synthetic cannabinoids and their impact on neurodevelopmental processes
The mechanistic regulation of neuronal processes, namely during neuronal development, by the endocannabinoid system is reviewed, and the potential of SCs to modulate such mechanisms and subsequently disrupt proper neurodevelopment is developed.
Modulatory effects of cannabinoids on brain neurotransmission
The present review has summarized the currently available pre‐clinical and clinical data on the interactions of CB1 and cannabinoid type‐2 receptors (CB2) with the central neurotransmitters; dopamine, serotonin, noradrenaline, GABA, glutamate and opioids.
Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice
Test in mice the potential therapeutic use of pregnenolone against acute psychotic-like effects of Δ9-tetrahydrocannabinol, the main psychoactive component of cannabis found that it blocks a wide spectrum of THC-induced endophenotypes typically associated with psychotic- like states, including impairments in cognitive functions, somatosensory gating and social interaction.
Synthetic and Non-synthetic Cannabinoid Drugs and Their Adverse Effects-A Review From Public Health Prospective
Given the growing popularity in the use of cannabinoid-based drugs and their harmful potential, there is a need for further research in this field.
GABA Deficits Enhance the Psychotomimetic Effects of Δ9-THC
There is strong support for the existence of a GABA deficit in schizophrenia, the proportion of schizophrenia patients with this deficit is not known, and it is conceivable that combinations of these factors may coexist and have additive or synergistic effects on increasing vulnerability to THC effects.
Cannabinoids and the expanded endocannabinoid system in neurological disorders
The biology of cannabinoids, the endocannabinoid system and the expanded endoc cannabinoidoid system are outlined and the involvement in and clinical relevance of these systems and the therapeutic potential of cannabinoids across the spectrum of neurological disease are discussed.
Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System
It is believed that the therapeutic significance of cannabinoids is masked by the adverse effects and here alternative strategies are discussed to take therapeutic advantage of cannabinoids.
The effects of Δ9-tetrahydrocannabinol on the dopamine system
The effects of Δ9-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, are a pressing concern for global mental health and there is conflicting evidence from human and animal studies concerning the effects of THC on the dopamine system.