• DOI:10.1096/fasebj.2.14.2846397
Corpus ID: 46552755

Cannabinoids and pain responses: a possible role for prostaglandins

@article{Burstein1988CannabinoidsAP,
  title={Cannabinoids and pain responses: a possible role for prostaglandins},
  author={S. Burstein and K. Hull and S. Hunter and V. Latham},
  journal={The FASEB Journal},
  year={1988},
  volume={2},
  pages={3022 - 3026}
}

S. Burstein, K. Hull, +1 author V. Latham

Published 1988

Chemistry, Medicine

The FASEB Journal

The principal metabolite of Δ1‐THC, Δ1‐THC‐7‐oic acid exhibits significant analgesic action in the mouse hot plate test. The parent Δ1‐THC has a similar effect when measured at later time points; however, 10 min after drug administration, a pronounced hyperalgesia is seen. This hyperalgesia can be inhibited by prior administration of either indomethacin or Δ1‐THC‐7‐oic acid, presumably because of their ability to inhibit eicosanoid synthesis. Administration of prostaglandin E2 (PGE2), at doses… CONTINUE READING

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