Cannabinoids and pain responses: a possible role for prostaglandins

@article{Burstein1988CannabinoidsAP,
  title={Cannabinoids and pain responses: a possible role for prostaglandins},
  author={Sumner H Burstein and Keith M. Hull and Sheila A. Hunter and V Latham},
  journal={The FASEB Journal},
  year={1988},
  volume={2},
  pages={3022 - 3026}
}
The principal metabolite of Δ1‐THC, Δ1‐THC‐7‐oic acid exhibits significant analgesic action in the mouse hot plate test. The parent Δ1‐THC has a similar effect when measured at later time points; however, 10 min after drug administration, a pronounced hyperalgesia is seen. This hyperalgesia can be inhibited by prior administration of either indomethacin or Δ1‐THC‐7‐oic acid, presumably because of their ability to inhibit eicosanoid synthesis. Administration of prostaglandin E2 (PGE2), at doses… 

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