Cannabinoids and pain responses: a possible role for prostaglandins

  title={Cannabinoids and pain responses: a possible role for prostaglandins},
  author={Sumner H Burstein and Keith M. Hull and Sheila A. Hunter and V Latham},
  journal={The FASEB Journal},
  pages={3022 - 3026}
The principal metabolite of Δ1‐THC, Δ1‐THC‐7‐oic acid exhibits significant analgesic action in the mouse hot plate test. The parent Δ1‐THC has a similar effect when measured at later time points; however, 10 min after drug administration, a pronounced hyperalgesia is seen. This hyperalgesia can be inhibited by prior administration of either indomethacin or Δ1‐THC‐7‐oic acid, presumably because of their ability to inhibit eicosanoid synthesis. Administration of prostaglandin E2 (PGE2), at doses… 

Cannabimimetic Properties of Ajulemic Acid

It is shown that AJA, like Δ9-THC, exhibits psychoactive and therapeutic effects at nearly equal doses in preclinical models, suggesting similar limitations in their putative therapeutic profiles.

Further studies on the antinociceptive effects ofΔ acid

The findings suggest that THC-7-oic acid probably acts by mechanisms similar to the NSAIDs and that the above mentioned experimental conditions can greatly influence the outcome of studies with this agent.

Eicosanoid mediation of cannabinoid actions.

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    Bioorganic & medicinal chemistry
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A portion of the work done by investigators interested in separating the medicinal properties of marijuana from its psychoactive effects is reviewed, finding several marijuana constituents, the carboxylic acid metabolites of tetrahydrocannabinol, and synthetic analogs are free of cannabimimetic central nervous system activity, do not produce behavioral changes in humans, and are effective antiinflammatory and analgesic agents.

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Morphine, enkephalins, opiate antagonists and cyclic guanosine 3',5'-monophosphate have a peripheral analgesic effect in the prostaglandin hyperalgesia test.

The ring test: a quantitative method for assessing the ‘cataleptic’ effect of cannabis in mice

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    British journal of pharmacology
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It is concluded that Δ1‐tetrahydrocannabinol (Δ1‐THC) is largely responsible for the effect of cannabis extract on mobility; the potency ratio of Δ1-THC to cannabis extract is between 10 and 20.

Analgesic properties of the tetrahydrocannabinols, their metabolites, and analogs.

It is suggested that metabolism to 11-hydroxy congeners may be necessary for the mediation of analgesic activity in the mouse hot-plate test but not for other pharmacologic effects produced by these substances which the authors have examined.


If the authors accept that these types of inflammation are neurally mediated (via axon reflexes), then it may be suggested that aspirin acts by blocking neurogenic inflammation, perhaps by preventing release of the antidromic neurohumoral mediator or by antagonizing its action.

Prostacyclin-stimulating drugs: new prospects.

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A preliminary trial of oral delta-9-tetrahydrocannabinol (THC) demonstrated an analgesic effect of the drug in patients experiencing cancer pain, and pain relief significantly superior to placebo was demonstrated at high dose levels.

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