Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor.

@article{Mackie1995CannabinoidsAA,
  title={Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor.},
  author={Ken Mackie and Yinzhi Lai and Ruth E. Westenbroek and Rory Mitchell},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1995},
  volume={15 10},
  pages={6552-61}
}
Rat brain cannabinoid receptor (CB-1) was stably transfected into the murine tumor line AtT-20 to study its coupling to inwardly rectifying potassium currents (Kir) and high voltage-activated calcium currents (ICa). In cells expressing CB-1 ("A-2" cells), cannabinoid agonist potently and stereospecifically activated Kir via a pertussis toxin-sensitive G protein. ICa in A-2 cells was sensitive to dihydropyridines and omega CTX MVIIC, less so to omega CgTX GVIA and insensitive to omega Aga IVa… CONTINUE READING
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Immunocytochemical identification and subcellular distribution of the cq , subunits of brain calcium channels

  • RE Westenbroek, T Sakurai, +4 authors WA Catterall
  • J Neurosci
  • 1995
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