Cannabinoids Stimulate Fibroblastic Colony Formation by Bone Marrow Cells Indirectly via CB2 Receptors

@article{Scutt2006CannabinoidsSF,
  title={Cannabinoids Stimulate Fibroblastic Colony Formation by Bone Marrow Cells Indirectly via CB2 Receptors},
  author={Andrew Scutt and Elizabeth Mae Williamson},
  journal={Calcified Tissue International},
  year={2006},
  volume={80},
  pages={50-59}
}
  • Andrew Scutt, Elizabeth Mae Williamson
  • Published 2006
  • Medicine, Biology
  • Calcified Tissue International
  • Recently, the cannabinoid receptors CB1 and CB2 were shown to modulate bone formation and resorption in vivo, although little is known of the mechanisms underlying this. The effects of cannabinoids on mesenchymal stem cell (MSC) recruitment in whole bone marrow were investigated using either the fibroblastic colony-forming unit (CFU-f) assay or high-density cultures of whole bone marrow. Levels of the CB1 and CB2 receptors were assessed by flow cytometry. Treatment of CFU-f cultures with the… CONTINUE READING

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