Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway*

@article{GmezdelPulgar2002CannabinoidsPA,
  title={Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway*},
  author={Teresa G{\'o}mez del Pulgar and Mar{\'i}a L. de Ceballos and Manuel Guzm{\'a}n and Guillermo Velasco},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={36527 - 36533}
}
Cannabinoids, the active components of marijuana and their endogenous counterparts, exert many of their actions on the central nervous system by binding to the CB1cannabinoid receptor. Different studies have shown that cannabinoids can protect neural cells from different insults. However, those studies have been performed in neurons, whereas no attention has been focused on glial cells. Here we used the pro-apoptotic lipid ceramide to induce apoptosis in astrocytes, and we studied the… 

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