Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells

@article{Kim2011CannabinoidsII,
  title={Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic $\beta$-Cells},
  author={Wook Kim and M. Doyle and Zhuo Liu and Q. Lao and Yu-Kyong Shin and O. Carlson and Hee Seung Kim and Sam Thomas and J. Napora and E. K. Lee and R. Moaddel and Y. Wang and Stuart Maudsley and B. Martin and R. Kulkarni and J. Egan},
  journal={Diabetes},
  year={2011},
  volume={60},
  pages={1198 - 1209}
}
OBJECTIVE Optimal glucose homeostasis requires exquisitely precise adaptation of the number of insulin-secreting β-cells in the islets of Langerhans. Insulin itself positively regulates β-cell proliferation in an autocrine manner through the insulin receptor (IR) signaling pathway. It is now coming to light that cannabinoid 1 receptor (CB1R) agonism/antagonism influences insulin action in insulin-sensitive tissues. However, the cells on which the CB1Rs are expressed and their function in islets… Expand
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References

SHOWING 1-10 OF 53 REFERENCES
Cannabinoid receptors regulate Ca2+ signals and insulin secretion in pancreatic β-cell
Cannabinoid Receptors are Coupled to Stimulation of Insulin Secretion from Mouse MIN6 β-cells
The cannabinoid CB1 receptor is expressed in pancreatic delta-cells.
Presence of functional cannabinoid receptors in human endocrine pancreas
Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines.
...
1
2
3
4
5
...