Cannabinoids Induce Pancreatic β-Cell Death by Directly Inhibiting Insulin Receptor Activation

@article{Kim2012CannabinoidsIP,
  title={Cannabinoids Induce Pancreatic $\beta$-Cell Death by Directly Inhibiting Insulin Receptor Activation},
  author={Wook Kim and Q. Lao and Yu-Kyong Shin and O. Carlson and E. K. Lee and M. Gorospe and R. Kulkarni and J. Egan},
  journal={Science Signaling},
  year={2012},
  volume={5},
  pages={ra23 - ra23}
}
Activation of cannabinoid 1 receptors prevents insulin receptors from promoting β-cell survival in the pancreas. Death by Cannabinoids Cannabinoid receptors are located in the brain and in the periphery, where they mediate effects on mood, appetite, metabolism, and pain perception. In pancreatic β cells, cannabinoid 1 receptors inhibit insulin action. Kim et al. showed that cannabinoid 1 receptors also prevent prosurvival signaling through the insulin receptor by attenuating its activation… Expand
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