Cannabinoids Induce Cell Death and Promote P2X7 Receptor Signaling in Retinal Glial Progenitors in Culture

@article{Freitas2019CannabinoidsIC,
  title={Cannabinoids Induce Cell Death and Promote P2X7 Receptor Signaling in Retinal Glial Progenitors in Culture},
  author={H{\'e}rcules Rezende Freitas and Alinny Rosendo Isaac and Thayane Martins Silva and Geyzzara Oliveira Ferreira Diniz and Yara Santos Dabdab and Eduardo Cosendey Bockmann and Mar{\'i}lia Zaluar P. Guimar{\~a}es and Karin Costa Calaza and Fernando G. Mello and Ana L{\'u}cia Marques Ventura and Ricardo Augusto Melo Reis and Guilherme Rapozeiro França},
  journal={Molecular Neurobiology},
  year={2019},
  pages={1-15}
}
Development of progenitors in the embryonic retina is modulated by signaling molecules, and cannabinoid receptors are highly expressed in the early developing retina. Here, we investigated whether the CB1/CB2 receptor agonist WIN 5212-2 (WIN) modulated the proliferation, viability, and calcium responses in chick embryo retinal progenitors in culture. A decline in [3H]-thymidine incorporation was observed when cultures were incubated with 0.5–1.0 μM WIN, an effect that was mimicked by URB602 and… 
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