Cannabinoids Induce Cell Death and Promote P2X7 Receptor Signaling in Retinal Glial Progenitors in Culture

@article{Freitas2019CannabinoidsIC,
  title={Cannabinoids Induce Cell Death and Promote P2X7 Receptor Signaling in Retinal Glial Progenitors in Culture},
  author={H. R. Freitas and A. R. Isaac and Thayane Martins Silva and Geyzzara Oliveira Ferreira Diniz and Yara Santos Dabdab and E. Bockmann and M. Guimar{\~a}es and Karin Costa Calaza and F. G. Mello and A. L. Ventura and R. A. Melo Reis and Guilherme Rapozeiro França},
  journal={Molecular Neurobiology},
  year={2019},
  pages={1-15}
}
  • H. R. Freitas, A. R. Isaac, +9 authors Guilherme Rapozeiro França
  • Published 2019
  • Biology, Medicine
  • Molecular Neurobiology
  • Development of progenitors in the embryonic retina is modulated by signaling molecules, and cannabinoid receptors are highly expressed in the early developing retina. Here, we investigated whether the CB1/CB2 receptor agonist WIN 5212-2 (WIN) modulated the proliferation, viability, and calcium responses in chick embryo retinal progenitors in culture. A decline in [3H]-thymidine incorporation was observed when cultures were incubated with 0.5–1.0 μM WIN, an effect that was mimicked by URB602 and… CONTINUE READING

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