Cannabinoids: reward, dependence, and underlying neurochemical mechanisms—a review of recent preclinical data

@article{Tanda2003CannabinoidsRD,
  title={Cannabinoids: reward, dependence, and underlying neurochemical mechanisms—a review of recent preclinical data},
  author={Gianluigi Tanda and Steven R. Goldberg},
  journal={Psychopharmacology},
  year={2003},
  volume={169},
  pages={115-134}
}
Starting with the discovery of an endogenous brain cannabinoid system with specific receptors and endogenous ligands, research in the cannabinoid field has accelerated dramatically over the last 15 years. Cannabis is the most used illicit psychotropic substance in the world but only recently have reliable preclinical models become available for investigating the rewarding and dependence-producing actions of its psychoactive constituent, Δ9-tetrahydrocannabinol (THC). The goal of this review is… CONTINUE READING
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