Cannabinoid tolerance and dependence: A review of studies in laboratory animals

  title={Cannabinoid tolerance and dependence: A review of studies in laboratory animals},
  author={Sara Gonz{\'a}lez and M. Cebeira and J. Fern{\'a}ndez-Ruiz},
  journal={Pharmacology Biochemistry and Behavior},
  • Sara González, M. Cebeira, J. Fernández-Ruiz
  • Published 2005
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
  • Two are the issues on cannabis addiction that provoke more controversy from a research perspective. The first one is related to the development of tolerance phenomena and, in particular, of a dependence state after chronic cannabinoid consumption, with appearance of withdrawal signs when this is interrupted, that would be (or not) comparable to those observed for other drugs. A second controversial issue is related to the possibility that chronic cannabinoid consumption may increase the risk to… CONTINUE READING
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