Cannabinoid tolerance and dependence: A review of studies in laboratory animals

@article{Gonzlez2005CannabinoidTA,
  title={Cannabinoid tolerance and dependence: A review of studies in laboratory animals},
  author={Sara Gonz{\'a}lez and Maribel Cebeira and Javier Fern{\'a}ndez-Ruiz},
  journal={Pharmacology Biochemistry and Behavior},
  year={2005},
  volume={81},
  pages={300-318}
}
Two are the issues on cannabis addiction that provoke more controversy from a research perspective. The first one is related to the development of tolerance phenomena and, in particular, of a dependence state after chronic cannabinoid consumption, with appearance of withdrawal signs when this is interrupted, that would be (or not) comparable to those observed for other drugs. A second controversial issue is related to the possibility that chronic cannabinoid consumption may increase the risk to… 
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