Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies.

  title={Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies.},
  author={Anastasia Suraev and Nathaniel S. Marshall and Ryan Vandrey and Danielle McCartney and Melissa J. Benson and Iain S. McGregor and Ronald R. Grunstein and Camilla M. Hoyos},
  journal={Sleep medicine reviews},

Medical Cannabis and Cannabinoids for Impaired Sleep: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Medical cannabis and cannabinoids may improve impaired sleep among people living with chronic pain, but the magnitude of benefit is likely small.

Cannabinoids Exposure Levels and its Relation to Anxiety Symptoms and Sleep Disturbances: A Scoping Review Protocol

At least 60% of individuals with anxiety disorders report sleep disturbances. Shared physiological mechanisms might explain their co-occurrence. Scientific literature related to medical cannabis, a

The Effectiveness and Safety of Cannabidiol in Non-seizure-related Indications: A Systematic Review of Published Randomized Clinical Trials

While cannabidiol was generally safe and well tolerated even in high doses among the included studies, clearer dosing guidelines and increased regulation of cannabis-derived compounds are also needed.

Is There a Place for Medicinal Cannabis in Treating Patients with Sleep Disorders? What We Know so Far

This narrative review summarizes the highest quality clinical evidence currently available in relation to the use of medicinal cannabis for the treatment of sleep disorders including insomnia, obstructive sleep apnea, restless legs syndrome, rapid eye movement sleep behavior disorder, nightmare disorder and narcolepsy.

Potential Role of Cannabidiol on Sports Recovery: A Narrative Review

Evidence suggesting that CBD has the potential to be used as a part of the strategies to recover from fatigue and muscle damage related to physical and cognitive exertion in sports is examined.

The Effects of Cannabinoids on Sleep

It is shown that cannabis products have minimal to no effects on sleep disorders and may have deleterious effects in some individuals and further research examining the differential impact of the various types of cannabinoids that are currently available on each of these sleep disorders is required.

Treating insomnia symptoms with medicinal cannabis: a randomized, crossover trial of the efficacy of a cannabinoid medicine compared with placebo

Two weeks of nightly sublingual administration of a cannabinoid extract (ZTL-101) is well tolerated and improves insomnia symptoms and sleep quality in individuals with chronic insomnia symptoms.

Cannabidiol (CBD) in Rheumatic Diseases (Musculoskeletal Pain)

CBD has potential for relief of symptoms of pain, sleep, and mood disturbance in rheumatology patients, but sound clinical evidence is lacking and the healthcare community must urgently accrue sound evidence for effect.

Use of Cannabinoids for the Treatment of OSA

The current knowledge on cannabinoid use and its impact on the pathophysiology of OSA as well as its role as a potential management option are summarized and promising but insufficient regarding both efficacy and safety are summarized.



The use of cannabinoids for sleep: A critical review on clinical trials.

A critical review of clinical studies examining the effects of cannabinoids on subjective and objective measures of sleep found many of the studies suggested that cannabinoids could improve sleep quality, decrease sleep disturbances, and decrease sleep onset latency.

Cannabidiol in Anxiety and Sleep: A Large Case Series.

A large retrospective case series involving clinical application of CBD for anxiety and sleep complaints as an adjunct to usual treatment found CBD was well tolerated in all but 3 patients.

Cannabis, Cannabinoids, and Sleep: a Review of the Literature

The state of research on cannabis and sleep up to 2014 is summarized and synthetic cannabinoids such as nabilone and dronabinol may have short-term benefit for sleep apnea due to their modulatory effects on serotonin-mediated apneas.

Cannabis, Pain, and Sleep: Lessons from Therapeutic Clinical Trials of Sativex®, a Cannabis‐Based Medicine

No tolerance to the benefit of Sativex on pain or sleep, nor need for dosage increases have been noted in safety extension studies of up to four years, wherein 40–50% of subjects attained good or very good sleep quality, a key source of disability in chronic pain syndromes that may contribute to patients' quality of life.

The Effects of Nabilone on Sleep in Fibromyalgia: Results of a Randomized Controlled Trial

Nabilone is effective in improving sleep in patients with FM and is well tolerated, and low-dose nabilone given once daily at bedtime may be considered as an alternative to amitriptyline.

Therapeutic Uses of Cannabis on Sleep Disorders and Related Conditions.

This review will provide the latest evidence regarding the medical risks and potential therapeutic benefits of cannabis in managing patients with sleep disorders or those with other medical conditions who commonly suffer with sleep disturbance as an associated comorbidity.

Cannabis withdrawal and sleep: A systematic review of human studies.

Sleep was frequently interrupted during cannabis withdrawal, although the specific mechanisms of disruption remain unclear, and no definitive conclusion on the specific aspects of sleep that are affected is reached.

Are cannabidiol and Δ9‐tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

The evidence indicates that CBD and THCV are not rimonabant‐like in their action and thus appear very unlikely to produce unwanted CNS effects, illustrating how in vitro mechanistic studies do not always predict in vivo pharmacology and underlie the necessity of testing compounds in vivo before drawing any conclusion on their functional activity at a given target.