Cannabinoid receptors are absent in insects

@article{Mcpartland2001CannabinoidRA,
  title={Cannabinoid receptors are absent in insects},
  author={J. Mcpartland and V. Di Marzo and L. De Petrocellis and A. Mercer and M. Glass},
  journal={Journal of Comparative Neurology},
  year={2001},
  volume={436}
}
  • J. Mcpartland, V. Di Marzo, +2 authors M. Glass
  • Published 2001
  • Biology, Medicine
  • Journal of Comparative Neurology
  • The endocannabinoid system exerts an important neuromodulatory role in mammals. Knockout mice lacking cannabinoid (CB) receptors exhibit significant morbidity. The endocannabinoid system also appears to be phylogenetically ancient—it occurs in mammals, birds, amphibians, fish, sea urchins, leeches, mussels, and even the most primitive animal with a nerve network, the Hydra. The presence of CB receptors, however, has not been examined in terrestrial invertebrates (or any member of the Ecdysozoa… CONTINUE READING
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    References

    SHOWING 1-10 OF 49 REFERENCES
    Evidence for an endocannabinoid system in the central nervous system of the leech Hirudo medicinalis.
    • 56
    Characterisation of dopamine receptors in insect (Apis mellifera) brain
    • 39
    • Highly Influential
    Identification and characterization of the leech CNS cannabinoid receptor: coupling to nitric oxide release
    • 81
    Comparative biology of the endocannabinoid system
    • 102
    • Highly Influential
    Cannabinoid receptors and their endogenous agonists.
    • C. Felder, M. Glass
    • Chemistry, Medicine
    • Annual review of pharmacology and toxicology
    • 1998
    • 359
    • PDF
    Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.
    • 995
    • PDF
    Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity.
    • 86
    • Highly Influential
    • PDF