Cannabinoid receptors CB1 and CB2 form functional heteromers in brain.

@article{Calln2012CannabinoidRC,
  title={Cannabinoid receptors CB1 and CB2 form functional heteromers in brain.},
  author={Luis Salvo Call{\'e}n and E. {\'A}lvarez Moreno and Pedro Barroso-Chinea and David Moreno-Delgado and Areli Gonz{\'a}lez Cort{\'e}s and Josefa Mallol and Vicent Casad{\'o} and Jos{\'e} L Lanciego and Rafael Franco and Carmen Lluis and Enric I. Canela and Peter James McCormick},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 25},
  pages={
          20851-65
        }
}
Exploring the role of cannabinoid CB(2) receptors in the brain, we present evidence of CB(2) receptor molecular and functional interaction with cannabinoid CB(1) receptors. Using biophysical and biochemical approaches, we discovered that CB(2) receptors can form heteromers with CB(1) receptors in transfected neuronal cells and in rat brain pineal gland, nucleus accumbens, and globus pallidus. Within CB(1)-CB(2) receptor heteromers expressed in a neuronal cell model, agonist co-activation of CB… CONTINUE READING
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CB1 and CB2 Receptors Form Heteromers 20862 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • V. Marzo, C. Behl, B. Lutz
  • JUNE 15,
  • 2012

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