Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis

@article{Janero2009CannabinoidRA,
  title={Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis},
  author={David R Janero and Alexandros Makriyannis},
  journal={Expert Opinion on Emerging Drugs},
  year={2009},
  volume={14},
  pages={43 - 65}
}
The endogenous cannabinoid (CB) (endocannabinoid) signaling system is involved in a variety of (patho)physiological processes, primarily by virtue of natural, arachidonic acid-derived lipids (endocannabinoids) that activate G protein-coupled CB1 and CB2 receptors. A hyperactive endocannabinoid system appears to contribute to the etiology of several disease states that constitute significant global threats to human health. Consequently, mounting interest surrounds the design and profiling of… 

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