Cannabinoid receptor antagonism and inverse agonism in response to SR141716A on cAMP production in human and rat brain.

@article{Mato2002CannabinoidRA,
  title={Cannabinoid receptor antagonism and inverse agonism in response to SR141716A on cAMP production in human and rat brain.},
  author={Susana Mato and {\'A}ngel Pazos and Elsa Mar{\'i}a Valdiz{\'a}n},
  journal={European journal of pharmacology},
  year={2002},
  volume={443 1-3},
  pages={43-6}
}
The effects of cannabinoid drugs on cAMP production were examined in mammalian brain. The cannabinoid receptor agonist (R)-(+)-[2,3-dihydro-5-methyl-3-[(4-morpholinyl)methyl]pyrrolo[1,2,3,-d,e-1,4-benzoxazin-6-yl]-(1-naphthalenyl) methanone (WIN55,212-2) decreased forskolin-induced cAMP accumulation in a concentration-dependent manner (10(-8)-10(-5) M) in membranes from several rat and human brain regions, this effect being antagonized by 10(-5) M N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4… CONTINUE READING
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