Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures.

@article{Shen1996CannabinoidRA,
  title={Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures.},
  author={Maoxing Shen and Timothy M Piser and Virginia S Seybold and Stanley A Thayer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1996},
  volume={16 14},
  pages={4322-34}
}
Activation of cannabinoid receptors inhibits voltage-gated Ca2+ channels and activates K+ channels, reminiscent of other G-protein-coupled signaling pathways that produce presynaptic inhibition. We tested cannabinoid receptor agonists for effects on excitatory neurotransmission between cultured rat hippocampal neurons. Reducing the extracellular Mg2+ concentration to 0.1 mM elicited repetitive, transient increases in intracellular Ca2+ concentration ([Ca2+]i spikes) that resulted from bursts of… CONTINUE READING
Highly Influential
This paper has highly influenced 26 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS