Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death.

@article{Athanasiou2007CannabinoidRA,
  title={Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death.},
  author={Andriani Athanasiou and Anna B Clarke and Amy E. J. Turner and Nethia M Kumaran and Sara Vakilpour and Paul A. Smith and Dimitra Bagiokou and Tracey D Bradshaw and Andrew D Westwell and Lin Fang and Dileep N. Lobo and Cris S. Constantinescu and Vittorio Calabrese and Andrzej Loesch and Stephen P. H. Alexander and Richard H Clothier and David A. Kendall and Timothy Edward Bates},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={364 1},
  pages={131-7}
}
Time-lapse microscopy of human lung cancer (H460) cells showed that the endogenous cannabinoid anandamide (AEA), the phyto-cannabinoid Delta-9-tetrahydrocannabinol (THC) and a synthetic cannabinoid HU 210 all caused morphological changes characteristic of apoptosis. Janus green assays of H460 cell viability showed that AEA and THC caused significant increases in OD 595 nm at lower concentrations (10-50 microM) and significant decreases at 100 microM, whilst HU 210 caused significant decreases… CONTINUE READING
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