Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes.

@article{Ghosh2006CannabinoidRC,
  title={Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes.},
  author={Sharmistha Ghosh and Anju Preet and Jerome E. Groopman and Ramesh Kumar Ganju},
  journal={Molecular immunology},
  year={2006},
  volume={43 14},
  pages={
          2169-79
        }
}
Cannabinoids have been shown to influence the immune system. However, their immunomodulatory effects have not been extensively studied. In this investigation, we have observed that both primary and Jurkat T cells express a functional cannabinoid receptor 2 (CB(2)). Furthermore, both the synthetic cannabinoids CP55,940 and WIN55,212-2, as well as the CB(2)-selective agonist JWH-015, caused a significant inhibition of the chemokine CXCL12-induced and CXCR4-mediated chemotaxis of Jurkat T cells… CONTINUE READING
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