Cannabinoid receptor 2 mediates retention of immature B cells in bone marrow sinusoids

@inproceedings{Pereira2009CannabinoidR2,
  title={Cannabinoid receptor 2 mediates retention of immature B cells in bone marrow sinusoids},
  author={Jo{\~a}o Pedro D. Pereira and Jinping An and Ying Xu and Yong Huang and Jason G Cyster},
  booktitle={Nature Immunology},
  year={2009}
}
Immature B cells developing in the bone marrow are found in the parenchyma and sinusoids. The mechanisms that control the positioning of B cells in the sinusoids are not understood. Here we show that the integrin α4β1 (VLA-4) and its ligand VCAM-1 were required, whereas the chemokine receptor CXCR4 was dispensable, for sinusoidal retention of B cells. Instead, cannabinoid receptor 2 (CB2), a Gαi protein–coupled receptor upregulated in immature B cells, was required for sinusoidal retention… CONTINUE READING
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