Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization.

@article{Jiang2011CannabinoidR2,
  title={Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization.},
  author={Shuxian Jiang and Meritxell Alberich-Jord{\`a} and Radoslaw Zagozdzon and K. M. Parmar and Yigong Fu and Peter M. Mauch and Naheed Banu and Alexandros Makriyannis and Daniel G Tenen and Shalom Avraham and Jerome E. Groopman and Hava Karsenty Avraham},
  journal={Blood},
  year={2011},
  volume={117 3},
  pages={827-38}
}
Endocannabinoids are arachidonic acid derivatives and part of a novel bioactive lipid signaling system, along with their G-coupled cannabinoid receptors (CB₁ and CB₂) and the enzymes involved in their biosynthesis and degradation. However, their roles in hematopoiesis and hematopoietic stem and progenitor cell (HSPC) functions are not well characterized. Here, we show that bone marrow stromal cells express endocannabinoids (anandamide and 2-arachidonylglycerol), whereas CB₂ receptors are… CONTINUE READING
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