Cannabinoid receptor-2 agonist inhibits macrophage induced EMT in non-small cell lung cancer by downregulation of EGFR pathway.

Abstract

JWH-015, a cannabinoid receptor 2 (CB2) agonist has tumor regressive property in various cancer types. However, the underlying mechanism by which it acts in lung cancer is still unknown. Tumor associated macrophage (TAM) intensity has positive correlation with tumor progression. Also, macrophages recruited at the tumor site promote tumor growth by enhancing… (More)
DOI: 10.1002/mc.22451

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Cite this paper

@article{Ravi2016CannabinoidRA, title={Cannabinoid receptor-2 agonist inhibits macrophage induced EMT in non-small cell lung cancer by downregulation of EGFR pathway.}, author={Janani Ravi and Mohamad Elbaz and Nissar Ahmad Wani and Mohd Wasim Nasser and Ramesh Kumar Ganju}, journal={Molecular carcinogenesis}, year={2016}, volume={55 12}, pages={2063-2076} }