Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis.

Abstract

We report on seizures during anesthesia induction in animals treated with a cannabinoid receptor 1 (CB1R) antagonist for experimental sepsis. Animals received surgery for colon ascendens stent peritonitis-induced sepsis or sham surgery followed by treatment of CB1R antagonist, CB1R agonist, or placebo. Fourteen hours later, animals received pentobarbital or… (More)
DOI: 10.1213/ANE.0b013e318251dada

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