Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A.

@article{Aceto1995CannabinoidPW,
  title={Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A.},
  author={Mario D. G. Aceto and Susan M Scates and Iii John Adams Lowe and B R Martin},
  journal={European journal of pharmacology},
  year={1995},
  volume={282 1-3},
  pages={
          R1-2
        }
}
Precipitated withdrawal in rats chronically exposed to delta 9-tetrahydrocannabinol, the major psychoactive principle of the marijuana plant, was unequivocally demonstrated for the first time using a selective antagonist, SR 141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-1(2,4- dichloro-phenyl)-4-methyl-1H-pyrazole carboxamide.HCl). This demonstration should provide a powerful stimulus for the systematic study of dependency on the psychoactive cannabinoids. 
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