Cannabinoid pharmacology/therapeutics in chronic degenerative disorders affecting the central nervous system
@article{Aymerich2018CannabinoidPI, title={Cannabinoid pharmacology/therapeutics in chronic degenerative disorders affecting the central nervous system}, author={Maria S Aymerich and Ester As{\'o} and Miguel A Abellanas and Rosa Mar{\'i}a Tol{\'o}n and Jos{\'e} Antonio Ramos and Isidre Ferrer and Julián Romero and Javier Fern{\'a}ndez-Ruiz}, journal={Biochemical Pharmacology}, year={2018}, volume={157}, pages={67–84} }
57 Citations
Targeting the CB2 receptor and other endocannabinoid elements to delay disease progression in amyotrophic lateral sclerosis
- Biology, ChemistryBritish journal of pharmacology
- 2021
The evidence accumulated so far at the preclinical level supports the need to soon move towards the patients and initiate clinical trials to confirm the potential of cannabinoid‐based medicines as disease modifiers in ALS.
Distinctive Evidence Involved in the Role of Endocannabinoid Signalling in Parkinson’s Disease: A Perspective on Associated Therapeutic Interventions
- Biology, PsychologyInternational journal of molecular sciences
- 2020
These reviews delineate the reported evidence from the literature on the neuromodulatory role of the endocannabinoid system and expression of cannabinoid receptors in symptomatology, cause, and treatment of PD progression, wherein cannabinoid (CB) signalling experiences alterations of biphasic pattern during PD progression.
Cannabinoid Drugs-Related Neuroprotection as a Potential Therapeutic Tool Against Chemotherapy-Induced Cognitive Impairment
- Biology, PsychologyFrontiers in Pharmacology
- 2021
The neuroprotective role of the ECS, well described in other cognitive-related neuropathologies, seems to be able to reduce the activation of pro-inflammatory cytokines involved in the neuroinflammatory supraspinal processes underlying CICI.
Effect of Cannabidiol on the Neural Glyoxalase Pathway Function and Longevity of Several C. elegans Strains Including a C. elegans Alzheimer's Disease Model.
- BiologyACS chemical neuroscience
- 2022
It is determined that a limited amount of Cannabidiol can prevent methylglyoxal-mediated cellular damage through enhancement of the neural glyoxalase pathway and extend the lifespan and survival of C. elegans, including a transgenic C. coli strain modeling Alzheimer's disease.
Analogues of cannabinoids as multitarget drugs in the treatment of Alzheimer's disease.
- Biology, ChemistryEuropean journal of pharmacology
- 2021
Potentiation of amyloid beta phagocytosis and amelioration of synaptic dysfunction upon FAAH deletion in a mouse model of Alzheimer's disease
- BiologyJournal of neuroinflammation
- 2021
The chronic enhancement of the endocannabinoid tone rescues hippocampal synaptic plasticity in the 5xFAD mouse model and supports the therapeutic potential of modulating, rather than suppressing, neuroinflammation in Alzheimer's disease.
Possible therapeutic applications of cannabis in the neuropsychopharmacology field
- Psychology, MedicineEuropean Neuropsychopharmacology
- 2020
Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology
- BiologyMolecules
- 2019
How cannabinoids act as potent regulators of NSC biology and their potential to modulate several neurogenic features in the context of pathophysiology are reviewed.
Role of cannabinoids in alcohol-induced neuroinflammation
- BiologyProgress in Neuro-Psychopharmacology and Biological Psychiatry
- 2021
Cannabinoids as Glial Cell Modulators in Ischemic Stroke: Implications for Neuroprotection
- Biology, MedicineFrontiers in Pharmacology
- 2022
Current findings on the potential promising contribution of the endocannabinoid system pharmacological manipulation in glial cells for the treatment of ischemic stroke are recapitulate.
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The cellular and molecular mechanisms, and the signaling pathways, underlying these neuroprotective properties, including the control of glutamate homeostasis, calcium influx, the toxicity of reactive oxygen species, glial activation and other inflammatory events; and the induction of autophagy are described.
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