Cannabinoid modulation of the reinforcing and motivational properties of heroin and heroin-associated cues in rats

@article{Vries2003CannabinoidMO,
  title={Cannabinoid modulation of the reinforcing and motivational properties of heroin and heroin-associated cues in rats},
  author={Taco J. De Vries and Judith R. Homberg and Rob Binnekade and Halfdan S. Raas\o and Anton N M Schoffelmeer},
  journal={Psychopharmacology},
  year={2003},
  volume={168},
  pages={164-169}
}
Recently, we provided evidence for a cannabinoid mechanism in relapse to cocaine seeking in rats. There is also increasing evidence for functional cross-talk between cannabinoid and opioid systems in several physiological processes. This study was designed to evaluate whether the cannabinoid system plays a role in mediating the reinforcing and motivational effects of heroin and heroin-paired stimuli. Male Wistar rats were trained to self-administer heroin (50 μg/kg per infusion) on fixed (FR5… CONTINUE READING
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