Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

@article{Puighermanal2009CannabinoidMO,
  title={Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling},
  author={E. Puighermanal and G. Marsicano and Arnau Busquets-Garcia and B. Lutz and R. Maldonado and A. Ozaita},
  journal={Nature Neuroscience},
  year={2009},
  volume={12},
  pages={1152-1158}
}
Cognitive impairment is one of the most important negative consequences associated with cannabis consumption. We found that CB1 cannabinoid receptor (CB1R) activation transiently modulated the mammalian target of rapamycin (mTOR)/p70S6K pathway and the protein synthesis machinery in the mouse hippocampus, which correlated with the amnesic properties of delta9-tetrahydrocannabinol (THC). In addition, non-amnesic doses of either the mTOR blocker rapamycin or the protein synthesis inhibitor… Expand
Pharmacological activation of CB1 receptor modulates long term potentiation by interfering with protein synthesis
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