Cannabinoid modulation of chronic mild stress-induced selective enhancement of trace fear conditioning in adolescent rats.

@article{Reich2013CannabinoidMO,
  title={Cannabinoid modulation of chronic mild stress-induced selective enhancement of trace fear conditioning in adolescent rats.},
  author={Christian G Reich and Anthony N Iskander and Michael S. Weiss},
  journal={Journal of psychopharmacology},
  year={2013},
  volume={27 10},
  pages={947-55}
}
History of stress is considered a major risk factor for the development of major depression and posttraumatic stress disorder (PTSD). Elucidating the neurobiological mechanisms of Pavlovian fear conditioning may provide insight into the etiology of PTSD. In the current study, adolescent male Sprague-Dawley rats were exposed to 3 weeks of a chronic-mild-unpredictable stress (CMS) protocol. Immediately following the CMS, the animals were subjected to hippocampal-dependent (trace and contextual… CONTINUE READING
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