Cannabinoid-mediated short-term plasticity in hippocampus

  title={Cannabinoid-mediated short-term plasticity in hippocampus},
  author={Margarita Zachariou and R{\"u}diger Thul},
  journal={Journal of Computational Neuroscience},
Endocannabinoids (eCBs) modulate both excitatory and inhibitory neurotransmission in hippocampus via activation of pre-synaptic cannabinoid receptors. Here, we present a model for cannabinoid mediated short-term depression of excitation (DSE) based on our recently developed model for the equivalent phenomenon of suppressing inhibition (DSI). Furthermore, we derive a simplified formulation of the calcium-mediated endocannabinoid synthesis that underlies short-term modulation of neurotransmission… CONTINUE READING
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