Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation.

@article{Cabral2001CannabinoidmediatedIO,
  title={Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation.},
  author={Guy A. Cabral and Karen Harmon and S J Carlisle},
  journal={Advances in experimental medicine and biology},
  year={2001},
  volume={493},
  pages={207-14}
}
Activated brain microglial cells release inflammatory mediators such as nitric oxide (NO) that may play important roles in central nervous system antibacterial, antiviral, and antitumor activities. However, excessive release of these factors has been postulated to elicit immune-mediated neurodegenerative inflammatory processes and to cause brain injury. Recent studies using the rat animal model indicate that select cannabinoids may modulate production of these inflammatory factors. Treatment of… CONTINUE READING