Cannabinoid-mediated disinhibition and working memory: dynamical interplay of multiple feedback mechanisms in a continuous attractor model of prefrontal cortex.

@article{Carter2007CannabinoidmediatedDA,
  title={Cannabinoid-mediated disinhibition and working memory: dynamical interplay of multiple feedback mechanisms in a continuous attractor model of prefrontal cortex.},
  author={Eugene Carter and Xiao-Jing Wang},
  journal={Cerebral cortex},
  year={2007},
  volume={17 Suppl 1},
  pages={i16-26}
}
Recurrent excitation is believed to underlie persistent neural activity observed in the prefrontal cortex and elsewhere during working memory. However, other positive and negative feedback mechanisms, operating on disparate timescales, may also play significant roles in determining the behavior of a working memory circuit. In this study, we examined dynamical interactions of multiple feedback mechanisms in a biophysically based neural model of spatial working memory. In such continuous… CONTINUE READING
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