Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees.

  title={Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees.},
  author={Niklas Schuelert and Jason J McDougall},
  journal={Arthritis and rheumatism},
  volume={58 1},
OBJECTIVE To determine whether local administration of the cannabinoid 1 (CB(1)) receptor agonist arachidonyl-2-chloroethylamide (ACEA) can modulate joint nociception in control rat knee joints and in experimental osteoarthritis (OA). METHODS OA was induced in male Wistar rats by intraarticular injection of 3 mg of sodium mono-iodoacetate, with a recovery period of 14 days. Electrophysiologic recordings were made of knee joint primary afferent nerve fibers in response to normal rotation and… CONTINUE READING
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