Cannabinoid mechanism in reinstatement of heroin-seeking after a long period of abstinence in rats.

@article{Fattore2003CannabinoidMI,
  title={Cannabinoid mechanism in reinstatement of heroin-seeking after a long period of abstinence in rats.},
  author={L Fattore and M Sabrina Spano and Gregorio Cossu and Serena Deiana and Walter Fratta},
  journal={The European journal of neuroscience},
  year={2003},
  volume={17 8},
  pages={1723-6}
}
Because opioid and cannabinoid systems have been reported to interact in the modulation of addictive behaviour, this study was aimed at investigating the ability of cannabinoid agents to reinstate or prevent heroin-seeking behaviour after a prolonged period of extinction. In rats previously trained to self-administer heroin intravenously, non-contingent non-reinforced priming administrations of heroin and cannabinoids were presented after long-term extinction, and lever pressing following… CONTINUE READING

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